Using medication to supposedly cure disease or ameliorate uncomfortable symptoms has become a part of our lives in Western culture. It is a part of the "pill for every ill" mentality that came about in the 1950s subsequent to the development of antibiotics and then tranquilizers. The ability to kill bacteria using antibiotics, thus literally saving thousand lives from the ravages of simple infections, naturally led to the idea that other medications might do the same for other diseases. However, over half a century later the medical profession finds itself in a very awkward and embarrassing position. An editorial in the prestigious New England Journal of Medicine by Dr. Jerry Avorn in November 2006 opens with the following paragraph -
"September 30 is becoming a day of infamy for drug safety. On that date in 2004 Merck announced that rofecoxib (Vioxx) doubled the risk of myocardial infarction [heart attack] and stroke and the company withdrew the drug from the market after 5 years of use in more than 20 million patients." If this was an isolated situation, then my concern might be less. The problem is that this is a class of drugs known as NSAIDS, or non-steroidal anti-inflammatories -- perhaps better known to you as aspirin, ibuprofen, Advil®, Tylenol®, etc. Now make no mistake about it, these drugs are effective in relieving pain from acute illness, and indeed they were supposed to be used that way. These long-term side effects that are being discovered are only being brought to light because long-term testing of these drugs does not take place until after they come to market! It takes literally millions of dollars to bring a drug to market these days, and pharmaceutical companies simply do not do long-term testing on all new medications, in the race to have the latest blockbuster drug. So who becomes the guinea pig?
The answer is that you become the guinea pig after the drug is initially approved; and it is only after long periods of time with use by many people that these side effects are coming to light. You may recall, particularly if you are woman, that early in the millennium conjugated estrogens, better known as Premarin®, were found to increase heart disease as opposed to decreasing it -- the latter was a claim the drug companies and doctors had made for over 15 years. There was also a slight increase in the incidence of breast cancer. Women had been the subject of a huge uncontrolled experiment. Since that time hundreds of thousands of women have stopped taking conjugated estrogens and guess what? A recent study in 2006 showed that the incidence of breast cancer had decreased significantly over the last 5 years since women have decreased their intake of conjugated estrogens. Coincidence? Perhaps. More likely that the impact of huge numbers of women decreasing conjugated estrogens may actually be decreasing the incidence of breast cancer.
More concerning is that this is becoming a trend. The latest drug to receive a seal of disapproval is the anti-diabetic medication rosiglitazone. All that glitters is not gold! A large analysis in a 2007 study, again in the New England Journal of Medicine, showed a significant increase in the number heart attacks and death from heart disease in patients taking this medication. It's bad enough that diabetes itself causes increased heart problems; we do not need a drug that is supposed to help control diabetes actually increasing death from heart attack!
Do you want to think twice before taking any drugs on a long-term basis? Absolutely. Many of these drugs were developed for acute pain situations -- not always for long-term use in ongoing osteoarthritis or other chronic illness. All these medications are foreign to our bodies, and they not only target those areas of our bodies that are in pain, say for example in the case of Vioxx, but they also target other areas of the body such as our blood vessels and stomach lining causing them to be affected in adverse ways through increased heart disease, or gastric upset and potential bleeding.
Adverse drug reactions were found to be one of the six leading causes of hospital deaths, reported in the Journal American Medical Association in 1997. Why are we taking drugs that are supposed to help us when they are actually killing us? It's a good question that cannot be answered in this short article.
These adverse effects are not limited to pain killers, hormone replacement therapy, and anti-diabetes drugs, but have also been found to be significant in antidepressants that are prescribed to hundreds of thousands of people every year. A small increase in the suicide rate amongst those taking certain antidepressants, when pointed out by the psychiatric expert Dr. David Healey, resulted in his deferral from his upcoming position with the Canadian Association of Mental Health at the University of Toronto. A few years ago certain drug companies funded multiple clinical trials of their anti-depressants known as SSRIs - but they only reported the results of the favourable trials, and suppressed the unfavourable results! The impact of the pharmaceutical industry on medical science is both enormous and dangerous.
If you have to take medication then stick with the older medications that have been tried and true. You are better off in most cases because they have had the research behind them for many years, but... Lifestyle intervention on the other hand -- taking care of ourselves, eating healthy foods, exercising, relaxation, and just taking time to chill out have no adverse effects. They also have significant impact upon disease -- recent studies in Type II diabetes have shown that compared to diabetic drugs, lifestyle intervention was much more efficacious in keeping diabetes under control.
Take care of yourself - you're worth it. And if you want to read that editorial in the New England Journal of Medicine you can find it at by searching for http://content.nejm.org/cgi/reprint/355/21/2169 on a search engine.
Edward Leyton MD 2007 © Accessing Resources for Empowerment(TM) 2007
"September 30 is becoming a day of infamy for drug safety. On that date in 2004 Merck announced that rofecoxib (Vioxx) doubled the risk of myocardial infarction [heart attack] and stroke and the company withdrew the drug from the market after 5 years of use in more than 20 million patients." If this was an isolated situation, then my concern might be less. The problem is that this is a class of drugs known as NSAIDS, or non-steroidal anti-inflammatories -- perhaps better known to you as aspirin, ibuprofen, Advil®, Tylenol®, etc. Now make no mistake about it, these drugs are effective in relieving pain from acute illness, and indeed they were supposed to be used that way. These long-term side effects that are being discovered are only being brought to light because long-term testing of these drugs does not take place until after they come to market! It takes literally millions of dollars to bring a drug to market these days, and pharmaceutical companies simply do not do long-term testing on all new medications, in the race to have the latest blockbuster drug. So who becomes the guinea pig?
The answer is that you become the guinea pig after the drug is initially approved; and it is only after long periods of time with use by many people that these side effects are coming to light. You may recall, particularly if you are woman, that early in the millennium conjugated estrogens, better known as Premarin®, were found to increase heart disease as opposed to decreasing it -- the latter was a claim the drug companies and doctors had made for over 15 years. There was also a slight increase in the incidence of breast cancer. Women had been the subject of a huge uncontrolled experiment. Since that time hundreds of thousands of women have stopped taking conjugated estrogens and guess what? A recent study in 2006 showed that the incidence of breast cancer had decreased significantly over the last 5 years since women have decreased their intake of conjugated estrogens. Coincidence? Perhaps. More likely that the impact of huge numbers of women decreasing conjugated estrogens may actually be decreasing the incidence of breast cancer.
More concerning is that this is becoming a trend. The latest drug to receive a seal of disapproval is the anti-diabetic medication rosiglitazone. All that glitters is not gold! A large analysis in a 2007 study, again in the New England Journal of Medicine, showed a significant increase in the number heart attacks and death from heart disease in patients taking this medication. It's bad enough that diabetes itself causes increased heart problems; we do not need a drug that is supposed to help control diabetes actually increasing death from heart attack!
Do you want to think twice before taking any drugs on a long-term basis? Absolutely. Many of these drugs were developed for acute pain situations -- not always for long-term use in ongoing osteoarthritis or other chronic illness. All these medications are foreign to our bodies, and they not only target those areas of our bodies that are in pain, say for example in the case of Vioxx, but they also target other areas of the body such as our blood vessels and stomach lining causing them to be affected in adverse ways through increased heart disease, or gastric upset and potential bleeding.
Adverse drug reactions were found to be one of the six leading causes of hospital deaths, reported in the Journal American Medical Association in 1997. Why are we taking drugs that are supposed to help us when they are actually killing us? It's a good question that cannot be answered in this short article.
These adverse effects are not limited to pain killers, hormone replacement therapy, and anti-diabetes drugs, but have also been found to be significant in antidepressants that are prescribed to hundreds of thousands of people every year. A small increase in the suicide rate amongst those taking certain antidepressants, when pointed out by the psychiatric expert Dr. David Healey, resulted in his deferral from his upcoming position with the Canadian Association of Mental Health at the University of Toronto. A few years ago certain drug companies funded multiple clinical trials of their anti-depressants known as SSRIs - but they only reported the results of the favourable trials, and suppressed the unfavourable results! The impact of the pharmaceutical industry on medical science is both enormous and dangerous.
If you have to take medication then stick with the older medications that have been tried and true. You are better off in most cases because they have had the research behind them for many years, but... Lifestyle intervention on the other hand -- taking care of ourselves, eating healthy foods, exercising, relaxation, and just taking time to chill out have no adverse effects. They also have significant impact upon disease -- recent studies in Type II diabetes have shown that compared to diabetic drugs, lifestyle intervention was much more efficacious in keeping diabetes under control.
Take care of yourself - you're worth it. And if you want to read that editorial in the New England Journal of Medicine you can find it at by searching for http://content.nejm.org/cgi/reprint/355/21/2169 on a search engine.
Edward Leyton MD 2007 © Accessing Resources for Empowerment(TM) 2007
There are four basic principles to health:
1. Good nutrition
2. Good exercise
3. Good thinking and emotional states
4. Good self-care
These embrace the mind, body and spirit of good health and well-being. This article and Dr. Leyton's monthly newsletter addresses one or more or more of these principles. These health tips are short and simple. All tips, where applicable, are based on quality research that is being done in the medical field.
You can subscribe to the free newsletter by signing up at http://www.arfe.ca You will see links throughout the newsletter to take you to more detail if you wish...or you can simply read what's there.
1. Good nutrition
2. Good exercise
3. Good thinking and emotional states
4. Good self-care
These embrace the mind, body and spirit of good health and well-being. This article and Dr. Leyton's monthly newsletter addresses one or more or more of these principles. These health tips are short and simple. All tips, where applicable, are based on quality research that is being done in the medical field.
You can subscribe to the free newsletter by signing up at http://www.arfe.ca You will see links throughout the newsletter to take you to more detail if you wish...or you can simply read what's there.
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